peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
53019 |
4. Check minimum number of eventsNone |
53019 |
5. Include endpoints
|
59957 |
6. Filter based on genotype QC (FinnGen only) |
57901 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Nerve, nerve root and plexus disorders
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 456646 | 263582 | 190230 |
| Only index persons | 413502 | 244275 | 169227 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.59 | 7.55 | 5.32 |
| Only index persons | 7.95 | 8.98 | 6.46 |
| Median age at first event (years) | |||
| Whole population | 52.49 | 52.78 | 52.06 |
| Only index persons | 51.72 | 52.02 | 51.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 57901 | 35645 | 22256 |
| Unadjusted period prevalence (%) | 12.91 | 14.00 | 11.18 |
| Median age at first event (years) | 52.38 | 50.95 | 54.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_NERPLEX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NERPLEX | 0.987 [0.91, 1.07] | 0.744 |
| Birth year | 0.996 [0.99, 1.0] | 0.281 |
During the follow-up period (1.1.1998 — 31.12.2019), 24356 out of 194793 females with G6_NERPLEX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NERPLEX | 1.26 [1.16, 1.37] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 24482 out of 138926 males with G6_NERPLEX died.
Mortality risk
Mortality risk for people of age
years, who have G6_NERPLEX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.24% |
| 5 | 0.622% | 1.627% |
| 10 | 1.357% | 3.964% |
| 15 | 2.591% | 7.605% |
| 20 | 4.709% | 12.606% |
Relationships between endpoints
↥Index endpoint: G6_NERPLEX – Nerve, nerve root and plexus disorders
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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