Other and unspecified mononeuropathies of upper limb

G6_MONONPOTHUS

mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G56.8, G56.9
  • Hospital discharge: ICD-9 354[8-9]
  • Cause of death: ICD-10 G56.8, G56.9
  • Cause of death: ICD-9 354[8-9]

2 out of 7 registries used, show all original rules.

1012

4. Check minimum number of events

None

1012

5. Include endpoints

None

1012

6. Filter based on genotype QC (FinnGen only)

979

Control definitions (FinnGen only)

Control exclude G6_NERPLEX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8274 4003 4241
Only index persons 7776 3828 3948
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.12
Only index persons 0.15 0.14 0.15
Median age at first event (years)
Whole population 47.79 49.30 46.34
Only index persons 47.14 48.74 45.59

-FinnGen-

Key figures

All Female Male
Number of individuals 979 533 446
Unadjusted period prevalence (%) 0.22 0.21 0.22
Median age at first event (years) 47.95 46.61 49.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint G6_MONONPOTHUS and mortality.

Females

Parameter HR [95% CI] p-value
G6_MONONPOTHUS 1.214 [1.06, 1.39] 0.004
Birth year 0.999 [0.99, 1.01] 0.8

During the follow-up period (1.1.1998 — 31.12.2019), 397 out of 3043 females with G6_MONONPOTHUS died.

Males

Parameter HR [95% CI] p-value
G6_MONONPOTHUS 1.422 [1.24, 1.63] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 468 out of 3225 males with G6_MONONPOTHUS died.

Mortality risk

Mortality risk for people of age

years, who have G6_MONONPOTHUS.

N-year risk Females Males
1 0.087% 0.276%
5 0.669% 1.607%
10 1.97% 3.865%
15 4.024% 7.496%
20 7.219% 12.516%

Relationships between endpoints

Index endpoint: G6_MONONPOTHUS – Other and unspecified mononeuropathies of upper limb

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data