mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.
Other and unspecified mononeuropathies of upper limb
DOID EFO Endpoint Browser PheWeb
G6_MONONPOTHUS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1012 |
4. Check minimum number of eventsNone |
1012 |
5. Include endpointsNone |
1012 |
6. Filter based on genotype QC (FinnGen only) |
979 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified mononeuropathies of upper limb
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8274 | 4003 | 4241 |
| Only index persons | 7776 | 3828 | 3948 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.11 | 0.12 |
| Only index persons | 0.15 | 0.14 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 47.79 | 49.30 | 46.34 |
| Only index persons | 47.14 | 48.74 | 45.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 979 | 533 | 446 |
| Unadjusted period prevalence (%) | 0.22 | 0.21 | 0.22 |
| Median age at first event (years) | 47.95 | 46.61 | 49.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_MONONPOTHUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONONPOTHUS | 1.214 [1.06, 1.39] | 0.004 |
| Birth year | 0.999 [0.99, 1.01] | 0.8 |
During the follow-up period (1.1.1998 — 31.12.2019), 397 out of 3043 females with G6_MONONPOTHUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONONPOTHUS | 1.422 [1.24, 1.63] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 468 out of 3225 males with G6_MONONPOTHUS died.
Mortality risk
Mortality risk for people of age
years, who have G6_MONONPOTHUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.276% |
| 5 | 0.669% | 1.607% |
| 10 | 1.97% | 3.865% |
| 15 | 4.024% | 7.496% |
| 20 | 7.219% | 12.516% |
Relationships between endpoints
↥Index endpoint: G6_MONONPOTHUS – Other and unspecified mononeuropathies of upper limb
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data