mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.
Other and unspecified mononeuropathies, also in other diseases
DOID EFO Endpoint Browser PheWeb
G6_MONOOTHUNS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1040 |
4. Check minimum number of eventsNone |
1040 |
5. Include endpointsNone |
1040 |
6. Filter based on genotype QC (FinnGen only) |
1005 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified mononeuropathies, also in other diseases
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8773 | 4453 | 4216 |
| Only index persons | 7200 | 3834 | 3366 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.13 | 0.12 |
| Only index persons | 0.14 | 0.14 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 48.22 | 48.19 | 48.05 |
| Only index persons | 46.27 | 46.67 | 45.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1005 | 555 | 450 |
| Unadjusted period prevalence (%) | 0.22 | 0.22 | 0.23 |
| Median age at first event (years) | 47.60 | 44.77 | 51.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_MONOOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONOOTHUNS | 1.828 [1.56, 2.14] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.348 |
During the follow-up period (1.1.1998 — 31.12.2019), 319 out of 1961 females with G6_MONOOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONOOTHUNS | 1.597 [1.39, 1.83] | < 0.001 |
| Birth year | 0.984 [0.97, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 495 out of 2227 males with G6_MONOOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_MONOOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.196% | 0.284% |
| 5 | 1.076% | 1.748% |
| 10 | 2.466% | 4.278% |
| 15 | 4.818% | 8.049% |
| 20 | 8.637% | 13.827% |
Relationships between endpoints
↥Index endpoint: G6_MONOOTHUNS – Other and unspecified mononeuropathies, also in other diseases
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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