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Disorders of other and unspecified cranial nerves

DOID EFO Endpoint Browser PheWeb

G6_DISOTHUNS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G52.8, G52.9
  • Hospital discharge: ICD-9 — 3524|3529
  • Hospital discharge: ICD-8 — 3560[8-9]
  • Cause of death: ICD-10 — G52.8, G52.9
  • Cause of death: ICD-9 — 3524|3529
  • Cause of death: ICD-8 — 3560[8-9]

2 out of 7 registries used, show all original rules.

172

4. Check minimum number of events

None

172

5. Include endpoints

None

172

6. Filter based on genotype QC (FinnGen only)

165

Control definitions (FinnGen only)

Control exclude G6_NERPLEX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1570 846 707
Only index persons 1256 694 562
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.03 0.02
Median age at first event (years)
Whole population 52.04 52.68 50.94
Only index persons 49.33 50.00 48.49

-FinnGen-

Key figures

All Female Male
Number of individuals 165 82 83
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 47.08 42.53 51.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint G6_DISOTHUNS and mortality.

Females

Parameter HR [95% CI] p-value
G6_DISOTHUNS 1.896 [1.51, 2.38] < 0.001
Birth year 0.995 [0.99, 1.0] 0.224

During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 486 females with G6_DISOTHUNS died.

Males

Parameter HR [95% CI] p-value
G6_DISOTHUNS 1.575 [1.2, 2.06] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 418 males with G6_DISOTHUNS died.

Mortality risk

Mortality risk for people of age

years, who have G6_DISOTHUNS.

N-year risk Females Males
1 0.141% 0.319%
5 1.129% 1.779%
10 2.979% 4.367%
15 5.596% 8.369%
20 9.291% 13.813%

Relationships between endpoints

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Index endpoint: G6_DISOTHUNS – Disorders of other and unspecified cranial nerves

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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