peripheral nervous system disease: A disease involving the peripheral nervous system.
Other and unspecified nerve root and plexus disorders, also in other diseases
DOID EFO Endpoint Browser PheWeb
G6_ROOTPLEXOTHUNS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7287 |
4. Check minimum number of eventsNone |
7287 |
5. Include endpointsNone |
7287 |
6. Filter based on genotype QC (FinnGen only) |
6982 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified nerve root and plexus disorders, also in other diseases
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 45171 | 22065 | 22893 |
| Only index persons | 43174 | 21254 | 21920 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.63 | 0.63 | 0.64 |
| Only index persons | 0.81 | 0.78 | 0.84 |
| Median age at first event (years) | |||
| Whole population | 52.39 | 53.19 | 51.68 |
| Only index persons | 51.98 | 52.71 | 51.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6982 | 3836 | 3146 |
| Unadjusted period prevalence (%) | 1.54 | 1.51 | 1.58 |
| Median age at first event (years) | 54.13 | 52.91 | 55.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_ROOTPLEXOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ROOTPLEXOTHUNS | 1.116 [1.01, 1.24] | 0.034 |
| Birth year | 0.994 [0.99, 1.0] | 0.182 |
During the follow-up period (1.1.1998 — 31.12.2019), 1878 out of 17306 females with G6_ROOTPLEXOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ROOTPLEXOTHUNS | 1.143 [1.03, 1.27] | 0.011 |
| Birth year | 0.984 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2262 out of 17987 males with G6_ROOTPLEXOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_ROOTPLEXOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.202% |
| 5 | 0.549% | 1.193% |
| 10 | 1.621% | 2.904% |
| 15 | 3.157% | 5.689% |
| 20 | 5.518% | 9.527% |
Relationships between endpoints
↥Index endpoint: G6_ROOTPLEXOTHUNS – Other and unspecified nerve root and plexus disorders, also in other diseases
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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