No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1631 |
4. Check minimum number of eventsNone |
1631 |
5. Include endpointsNone |
1631 |
6. Filter based on genotype QC (FinnGen only) |
1589 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G57
Name in latin
Morbositas nervi ischiadici
Similar endpoints
↥List of similar endpoints to
Lesion of sciatic nerve
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19701 | 9844 | 9570 |
| Only index persons | 13546 | 7540 | 6006 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.28 | 0.27 |
| Only index persons | 0.26 | 0.28 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 45.13 | 45.57 | 44.49 |
| Only index persons | 41.89 | 43.07 | 40.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1589 | 728 | 861 |
| Unadjusted period prevalence (%) | 0.37 | 0.29 | 0.43 |
| Median age at first event (years) | 41.52 | 40.34 | 42.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_SCIALE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_SCIALE | 1.172 [0.97, 1.42] | 0.101 |
| Birth year | 0.997 [0.99, 1.01] | 0.488 |
During the follow-up period (1.1.1998 — 31.12.2019), 163 out of 1132 females with G6_SCIALE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_SCIALE | 1.186 [0.97, 1.45] | 0.102 |
| Birth year | 0.991 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 704 males with G6_SCIALE died.
Mortality risk
Mortality risk for people of age
years, who have G6_SCIALE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | 0.265% |
| 5 | 0.738% | 1.466% |
| 10 | 1.822% | 3.853% |
| 15 | 3.507% | 7.224% |
| 20 | 6.276% | 12.375% |
Relationships between endpoints
↥Index endpoint: G6_SCIALE – Lesion of sciatic nerve
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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