causalgia: Complex regional pain syndrome type 2 (CRPS2), or causalgia is a form of complex regional pain syndrome that develops after damage to a peripheral nerve and is characterized by spontaneous pain, allodynia and hyperalgesia , not necessarily limited to the territory of the injured nerve, as well as at some point, edema, changes in skin blood flow or sudomotor dysfunction in the pain area.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
558 |
4. Check minimum number of eventsNone |
558 |
5. Include endpointsNone |
558 |
6. Filter based on genotype QC (FinnGen only) |
540 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G56
Name in latin
Causalgia
Similar endpoints
↥List of similar endpoints to
Causalgia
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4108 | 2491 | 1591 |
| Only index persons | 3917 | 2418 | 1499 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.04 |
| Only index persons | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 47.72 | 47.94 | 47.37 |
| Only index persons | 47.48 | 47.68 | 47.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 540 | 376 | 164 |
| Unadjusted period prevalence (%) | 0.13 | 0.15 | 0.08 |
| Median age at first event (years) | 46.46 | 45.91 | 47.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_CAUSALGIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CAUSALGIA | 1.273 [1.05, 1.54] | 0.013 |
| Birth year | 0.999 [0.99, 1.01] | 0.825 |
During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 2156 females with G6_CAUSALGIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CAUSALGIA | 1.295 [1.08, 1.56] | 0.006 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 165 out of 1325 males with G6_CAUSALGIA died.
Mortality risk
Mortality risk for people of age
years, who have G6_CAUSALGIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.213% |
| 5 | 0.811% | 1.374% |
| 10 | 2.068% | 3.589% |
| 15 | 3.917% | 6.907% |
| 20 | 6.745% | 11.677% |
Relationships between endpoints
↥Index endpoint: G6_CAUSALGIA – Causalgia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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