tarsal tunnel syndrome: Tarsal tunnel syndrome is a nerve disorder that is characterized by pain in the ankle, foot, and toes. This condition is caused by compression of the posterior tibial nerve, which runs through a canal near the heel into the sole of the foot. When tissues around this nerve become inflamed, they can press on the nerve and cause the pain associated with tarsal tunnel syndrome.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
332 |
4. Check minimum number of eventsNone |
332 |
5. Include endpointsNone |
332 |
6. Filter based on genotype QC (FinnGen only) |
321 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G57
Name in latin
Syndroma canalis tarsi
Similar endpoints
↥List of similar endpoints to
Tarsal tunnel syndrome
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2313 | 1573 | 732 |
| Only index persons | 2188 | 1518 | 670 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.86 | 51.67 | 49.08 |
| Only index persons | 50.63 | 51.61 | 48.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 321 | 241 | 80 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.04 |
| Median age at first event (years) | 51.41 | 51.13 | 52.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_TARSTUN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TARSTUN | 0.804 [0.66, 0.97] | 0.026 |
| Birth year | 0.994 [0.99, 1.0] | 0.166 |
During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 1139 females with G6_TARSTUN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TARSTUN | 0.961 [0.76, 1.22] | 0.747 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 501 males with G6_TARSTUN died.
Mortality risk
Mortality risk for people of age
years, who have G6_TARSTUN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.209% |
| 5 | 0.458% | 1.193% |
| 10 | 1.154% | 2.996% |
| 15 | 2.191% | 5.581% |
| 20 | 4.018% | 9.683% |
Relationships between endpoints
↥Index endpoint: G6_TARSTUN – Tarsal tunnel syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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