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Other facial nerve disorders

DOID EFO Endpoint Browser PheWeb

G6_FACOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G51
  • Hospital discharge: ICD-9 — 351
  • Hospital discharge: excluded ICD-10 — G51.0
  • Hospital discharge: excluded ICD-9 — 3510
  • Cause of death: ICD-10 — G51
  • Cause of death: ICD-9 — 351
  • Cause of death: excluded ICD-10 — G51.0
  • Cause of death: excluded ICD-9 — 3510

2 out of 7 registries used, show all original rules.

954

4. Check minimum number of events

None

954

5. Include endpoints

None

954

6. Filter based on genotype QC (FinnGen only)

920

Control definitions (FinnGen only)

Control exclude G6_NERPLEX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G50-G59
Name in latin Morbositates nervi facialis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7545 4598 2892
Only index persons 6698 4159 2539
Unadjusted period prevalence (%)
Whole population 0.11 0.13 0.08
Only index persons 0.13 0.15 0.10
Median age at first event (years)
Whole population 54.85 55.37 53.90
Only index persons 53.10 53.57 52.33

-FinnGen-

Key figures

All Female Male
Number of individuals 920 614 306
Unadjusted period prevalence (%) 0.21 0.24 0.15
Median age at first event (years) 53.40 52.73 54.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint G6_FACOTH and mortality.

Females

Parameter HR [95% CI] p-value
G6_FACOTH 1.072 [0.96, 1.2] 0.232
Birth year 0.993 [0.98, 1.0] 0.123

During the follow-up period (1.1.1998 — 31.12.2019), 600 out of 3574 females with G6_FACOTH died.

Males

Parameter HR [95% CI] p-value
G6_FACOTH 1.074 [0.94, 1.22] 0.275
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 437 out of 2198 males with G6_FACOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_FACOTH.

N-year risk Females Males
1 0.101% 0.153%
5 0.581% 1.052%
10 1.446% 2.663%
15 2.94% 5.251%
20 5.264% 8.985%

Relationships between endpoints

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Index endpoint: G6_FACOTH – Other facial nerve disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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