spinal cord disease: A disease involving the spinal cord.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
408 |
4. Check minimum number of eventsNone |
408 |
5. Include endpointsNone |
408 |
6. Filter based on genotype QC (FinnGen only) |
397 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G54
Name in latin
Morbositates radicum nervorum lumbosacralium non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Lumbosacral root disorders, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3586 | 1888 | 1683 |
| Only index persons | 3295 | 1778 | 1517 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.07 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 57.09 | 56.62 | 57.51 |
| Only index persons | 56.44 | 55.99 | 56.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 397 | 231 | 166 |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | 0.08 |
| Median age at first event (years) | 54.77 | 52.24 | 58.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_LSROOT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSROOT | 1.109 [0.93, 1.32] | 0.251 |
| Birth year | 0.998 [0.99, 1.01] | 0.698 |
During the follow-up period (1.1.1998 — 31.12.2019), 198 out of 1477 females with G6_LSROOT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSROOT | 1.121 [0.94, 1.34] | 0.205 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 241 out of 1304 males with G6_LSROOT died.
Mortality risk
Mortality risk for people of age
years, who have G6_LSROOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.173% |
| 5 | 0.749% | 1.307% |
| 10 | 1.701% | 3.452% |
| 15 | 3.364% | 6.466% |
| 20 | 6.176% | 10.951% |
Relationships between endpoints
↥Index endpoint: G6_LSROOT – Lumbosacral root disorders, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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