carpal tunnel syndrome: Entrapment of the median nerve in the wrist that is characterized by numbness, tingling and painful movement.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
28596 |
4. Check minimum number of eventsNone |
28596 |
5. Include endpointsNone |
28596 |
6. Filter based on genotype QC (FinnGen only) |
27716 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G56
Name in latin
Syndroma canalis carpi
Similar endpoints
↥List of similar endpoints to
Carpal tunnel syndrome
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 197586 | 131488 | 65397 |
| Only index persons | 188924 | 126663 | 62261 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.11 | 3.77 | 1.83 |
| Only index persons | 3.91 | 4.66 | 2.38 |
| Median age at first event (years) | |||
| Whole population | 54.12 | 54.15 | 54.07 |
| Only index persons | 53.75 | 53.79 | 53.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 27716 | 19068 | 8648 |
| Unadjusted period prevalence (%) | 6.51 | 7.49 | 4.34 |
| Median age at first event (years) | 53.67 | 52.64 | 55.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_CARPTU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CARPTU | 0.916 [0.84, 0.99] | 0.037 |
| Birth year | 0.992 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 11743 out of 105909 females with G6_CARPTU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CARPTU | 0.864 [0.79, 0.94] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 7586 out of 53592 males with G6_CARPTU died.
Mortality risk
Mortality risk for people of age
years, who have G6_CARPTU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.058% | 0.174% |
| 5 | 0.429% | 1.035% |
| 10 | 1.08% | 2.625% |
| 15 | 2.11% | 4.945% |
| 20 | 3.705% | 8.318% |
Relationships between endpoints
↥Index endpoint: G6_CARPTU – Carpal tunnel syndrome
GWS hits: 40
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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