mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
254 |
4. Check minimum number of eventsNone |
254 |
5. Include endpointsNone |
254 |
6. Filter based on genotype QC (FinnGen only) |
247 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G58
Name in latin
Neuropathia intercostalis
Similar endpoints
↥List of similar endpoints to
Intercostal neuropathy
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1814 | 986 | 815 |
| Only index persons | 1687 | 950 | 737 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 55.78 | 56.59 | 54.97 |
| Only index persons | 55.47 | 56.25 | 54.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 247 | 131 | 116 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.06 |
| Median age at first event (years) | 57.17 | 55.28 | 59.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_ICNEUROP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ICNEUROP | 1.431 [1.19, 1.73] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 163 out of 876 females with G6_ICNEUROP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ICNEUROP | 1.58 [1.33, 1.88] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 723 males with G6_ICNEUROP died.
Mortality risk
Mortality risk for people of age
years, who have G6_ICNEUROP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.338% |
| 5 | 0.74% | 1.76% |
| 10 | 1.955% | 4.785% |
| 15 | 3.823% | 9.4% |
| 20 | 6.455% | 15.462% |
Relationships between endpoints
↥Index endpoint: G6_ICNEUROP – Intercostal neuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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