trigeminal neuralgia: Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
2058 |
4. Check minimum number of eventsNone |
2058 |
5. Include endpointsNone |
2058 |
6. Filter based on genotype QC (FinnGen only) |
1973 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G50
Name in latin
Neuralgia trigeminalis
Similar endpoints
↥List of similar endpoints to
Trigeminal neuralgia
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Pain (limb, back, neck, head abdominally)
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15546 | 10605 | 4805 |
| Only index persons | 13493 | 9534 | 3959 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.30 | 0.13 |
| Only index persons | 0.29 | 0.35 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 56.64 | 56.10 | 57.82 |
| Only index persons | 54.85 | 54.41 | 55.90 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1973 | 1384 | 589 |
| Unadjusted period prevalence (%) | 0.47 | 0.54 | 0.30 |
| Median age at first event (years) | 54.36 | 52.52 | 58.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_TRINEU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TRINEU | 1.008 [0.9, 1.12] | 0.882 |
| Birth year | 0.995 [0.99, 1.0] | 0.284 |
During the follow-up period (1.1.1998 — 31.12.2019), 1123 out of 7824 females with G6_TRINEU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TRINEU | 1.14 [1.0, 1.29] | 0.044 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 740 out of 3275 males with G6_TRINEU died.
Mortality risk
Mortality risk for people of age
years, who have G6_TRINEU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.199% |
| 5 | 0.637% | 1.285% |
| 10 | 1.475% | 3.1% |
| 15 | 2.921% | 5.997% |
| 20 | 5.04% | 10.216% |
Relationships between endpoints
↥Index endpoint: G6_TRINEU – Trigeminal neuralgia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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