No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
222037 |
6. Filter based on genotype QC (FinnGen only) |
212869 |
Control definitions (FinnGen only)
Control exclude
H7_EYEOTH
Extra metadata
First used in FinnGen datafreeze
DF3
Pain (limb, back, neck, head abdominally)
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2145944 | 1235030 | 893797 |
| Only index persons | 1919106 | 1129012 | 790094 |
| Unadjusted period prevalence (%) | |||
| Whole population | 30.90 | 35.37 | 24.97 |
| Only index persons | 36.83 | 41.50 | 30.16 |
| Median age at first event (years) | |||
| Whole population | 42.51 | 42.31 | 42.83 |
| Only index persons | 41.37 | 41.11 | 41.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 212869 | 134780 | 78089 |
| Unadjusted period prevalence (%) | 47.90 | 52.93 | 39.22 |
| Median age at first event (years) | 46.14 | 42.41 | 52.57 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint PAIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PAIN | 1.304 [1.21, 1.4] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 117277 out of 929900 females with PAIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PAIN | 1.519 [1.4, 1.64] | < 0.001 |
| Birth year | 0.98 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 104850 out of 673910 males with PAIN died.
Mortality risk
Mortality risk for people of age
years, who have PAIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.077% | 0.183% |
| 5 | 0.463% | 1.067% |
| 10 | 1.23% | 2.711% |
| 15 | 2.384% | 5.121% |
| 20 | 4.18% | 8.871% |
Relationships between endpoints
↥Index endpoint: PAIN – Pain (limb, back, neck, head abdominally)
GWS hits: 37
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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