fibromyalgia: A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3284 |
4. Check minimum number of eventsNone |
3284 |
5. Include endpointsNone |
3284 |
6. Filter based on genotype QC (FinnGen only) |
3166 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M79
Similar endpoints
↥List of similar endpoints to
Fibromyalgia
based on the number of shared cases.
Similar with more cases:
- Other soft tissue disorders, not elsewhere classified
- Finngen Rheumatological endpoints
- Soft tissue disorders
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16045 | 14591 | 1358 |
| Only index persons | 15875 | 14521 | 1354 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.42 | 0.04 |
| Only index persons | 0.49 | 0.53 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 53.72 | 53.98 | 51.70 |
| Only index persons | 53.82 | 54.02 | 51.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3166 | 2956 | 210 |
| Unadjusted period prevalence (%) | 1.09 | 1.16 | 0.11 |
| Median age at first event (years) | 53.54 | 53.46 | 54.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_FIBROMYALGIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FIBROMYALGIA | 1.246 [0.99, 1.57] | 0.063 |
| Birth year | 0.996 [0.99, 1.0] | 0.377 |
During the follow-up period (1.1.1998 — 31.12.2019), 436 out of 10974 females with M13_FIBROMYALGIA died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have M13_FIBROMYALGIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | No data |
| 5 | 0.767% | No data |
| 10 | 2.05% | No data |
| 15 | 3.976% | No data |
| 20 | 6.618% | No data |
Relationships between endpoints
↥Index endpoint: M13_FIBROMYALGIA – Fibromyalgia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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