musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]
Other soft tissue disorders, not elsewhere classified
DOID EFO Endpoint Browser PheWeb
M13_SOFTTISSUEOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
56748 |
4. Check minimum number of eventsNone |
56748 |
5. Include endpoints |
57822 |
6. Filter based on genotype QC (FinnGen only) |
55533 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M70-M79
Name in latin
Aliae morbositates textus mollis non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Other soft tissue disorders, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 461182 | 282951 | 175757 |
| Only index persons | 428764 | 267123 | 161641 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.86 | 8.10 | 4.91 |
| Only index persons | 8.44 | 9.82 | 6.17 |
| Median age at first event (years) | |||
| Whole population | 51.88 | 52.52 | 51.00 |
| Only index persons | 52.01 | 52.41 | 51.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 55533 | 37019 | 18514 |
| Unadjusted period prevalence (%) | 12.79 | 14.54 | 9.30 |
| Median age at first event (years) | 54.76 | 52.25 | 59.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SOFTTISSUEOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SOFTTISSUEOTH | 1.372 [1.25, 1.51] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.105 |
During the follow-up period (1.1.1998 — 31.12.2019), 30860 out of 221248 females with M13_SOFTTISSUEOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SOFTTISSUEOTH | 1.459 [1.31, 1.62] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 22071 out of 138048 males with M13_SOFTTISSUEOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SOFTTISSUEOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.066% | 0.294% |
| 5 | 0.629% | 1.704% |
| 10 | 1.598% | 3.968% |
| 15 | 3.116% | 7.587% |
| 20 | 5.77% | 12.373% |
Relationships between endpoints
↥Index endpoint: M13_SOFTTISSUEOTH – Other soft tissue disorders, not elsewhere classified
GWS hits: 13
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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