rheumatic disease: Inflammatory and degenerative diseases of connective tissue structures, such as arthritis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
5632 |
4. Check minimum number of eventsNone |
5632 |
5. Include endpointsNone |
5632 |
6. Filter based on genotype QC (FinnGen only) |
5449 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M79
Name in latin
Rheumatismus non specificatus
Similar endpoints
↥List of similar endpoints to
Rheumatism, unspecified
based on the number of shared cases.
Similar with more cases:
- Other soft tissue disorders, not elsewhere classified
- Soft tissue disorders
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 38864 | 33936 | 4778 |
| Only index persons | 36684 | 32408 | 4276 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.87 | 0.97 | 0.13 |
| Only index persons | 1.07 | 1.19 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 50.63 | 50.81 | 49.47 |
| Only index persons | 50.25 | 50.47 | 48.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5449 | 4887 | 562 |
| Unadjusted period prevalence (%) | 1.75 | 1.92 | 0.28 |
| Median age at first event (years) | 49.16 | 48.93 | 51.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_RHEUMATISM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_RHEUMATISM | 1.088 [1.0, 1.19] | 0.058 |
| Birth year | 0.993 [0.99, 1.0] | 0.1 |
During the follow-up period (1.1.1998 — 31.12.2019), 2691 out of 26878 females with M13_RHEUMATISM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_RHEUMATISM | 1.11 [0.99, 1.25] | 0.079 |
| Birth year | 0.99 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 530 out of 3428 males with M13_RHEUMATISM died.
Mortality risk
Mortality risk for people of age
years, who have M13_RHEUMATISM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.236% |
| 5 | 0.63% | 1.319% |
| 10 | 1.42% | 3.459% |
| 15 | 2.822% | 6.555% |
| 20 | 5.079% | 11.176% |
Relationships between endpoints
↥Index endpoint: M13_RHEUMATISM – Rheumatism, unspecified
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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