panniculitis: a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the fatty layer under the skin - panniculus adiposus). Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
342 |
4. Check minimum number of eventsNone |
342 |
5. Include endpointsNone |
342 |
6. Filter based on genotype QC (FinnGen only) |
325 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M79
Name in latin
Panniculitis non specificata
Similar endpoints
↥List of similar endpoints to
Panniculitis, unspecified
based on the number of shared cases.
Similar with more cases:
- Other soft tissue disorders, not elsewhere classified
- Soft tissue disorders
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2209 | 1489 | 709 |
| Only index persons | 2001 | 1370 | 631 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.09 | 58.14 | 57.96 |
| Only index persons | 57.31 | 57.27 | 57.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 325 | 216 | 109 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.05 |
| Median age at first event (years) | 57.30 | 54.30 | 63.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_PANNICULITISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PANNICULITISNAS | 1.38 [1.15, 1.66] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.527 |
During the follow-up period (1.1.1998 — 31.12.2019), 280 out of 1244 females with M13_PANNICULITISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PANNICULITISNAS | 1.738 [1.29, 2.34] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 552 males with M13_PANNICULITISNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_PANNICULITISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.178% | 0.309% |
| 5 | 0.897% | 1.926% |
| 10 | 2.107% | 4.525% |
| 15 | 4.121% | 8.675% |
| 20 | 7.064% | 14.637% |
Relationships between endpoints
↥Index endpoint: M13_PANNICULITISNAS – Panniculitis, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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