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Other specified/unspecified soft tissue disorders

EFO MESH Endpoint Browser PheWeb

M13_SOFTTISSUENAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M79.8, M79.9
  • Hospital discharge: ICD-9 — 729[8-9]
  • Hospital discharge: ICD-8 — 71798
  • Cause of death: ICD-10 — M79.8, M79.9
  • Cause of death: ICD-9 — 729[8-9]
  • Cause of death: ICD-8 — 71798

2 out of 7 registries used, show all original rules.

1830

4. Check minimum number of events

None

1830

5. Include endpoints

None

1830

6. Filter based on genotype QC (FinnGen only)

1775

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18802 12861 5715
Only index persons 14626 10470 4156
Unadjusted period prevalence (%)
Whole population 0.30 0.37 0.16
Only index persons 0.32 0.38 0.16
Median age at first event (years)
Whole population 50.42 51.16 48.60
Only index persons 47.70 48.86 44.75

-FinnGen-

Key figures

All Female Male
Number of individuals 1775 1259 516
Unadjusted period prevalence (%) 0.43 0.49 0.26
Median age at first event (years) 47.54 47.10 48.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_SOFTTISSUENAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_SOFTTISSUENAS 1.344 [1.19, 1.52] < 0.001
Birth year 0.995 [0.99, 1.0] 0.195

During the follow-up period (1.1.1998 — 31.12.2019), 709 out of 4984 females with M13_SOFTTISSUENAS died.

Males

Parameter HR [95% CI] p-value
M13_SOFTTISSUENAS 1.328 [1.14, 1.55] < 0.001
Birth year 0.988 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 2241 males with M13_SOFTTISSUENAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_SOFTTISSUENAS.

N-year risk Females Males
1 0.139% 0.302%
5 0.72% 1.633%
10 1.752% 3.926%
15 3.366% 7.535%
20 6.113% 13.091%

Relationships between endpoints

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Index endpoint: M13_SOFTTISSUENAS – Other specified/unspecified soft tissue disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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