No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
41378 |
4. Check minimum number of eventsNone |
41378 |
5. Include endpointsNone |
41378 |
6. Filter based on genotype QC (FinnGen only) |
39716 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M79
Name in latin
Melalgia
Similar endpoints
↥List of similar endpoints to
Pain in limb
based on the number of shared cases.
Similar with more cases:
- Other soft tissue disorders, not elsewhere classified
- Soft tissue disorders
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 328528 | 196590 | 130443 |
| Only index persons | 306752 | 186403 | 120349 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.82 | 5.63 | 3.64 |
| Only index persons | 5.97 | 6.85 | 4.59 |
| Median age at first event (years) | |||
| Whole population | 54.52 | 55.37 | 53.37 |
| Only index persons | 54.92 | 55.49 | 54.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 39716 | 25562 | 14154 |
| Unadjusted period prevalence (%) | 8.99 | 10.04 | 7.11 |
| Median age at first event (years) | 57.32 | 54.67 | 62.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_LIMBPAIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_LIMBPAIN | 1.285 [1.17, 1.41] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 25686 out of 158303 females with M13_LIMBPAIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_LIMBPAIN | 1.549 [1.39, 1.72] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 18641 out of 104226 males with M13_LIMBPAIN died.
Mortality risk
Mortality risk for people of age
years, who have M13_LIMBPAIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.256% |
| 5 | 0.698% | 1.589% |
| 10 | 1.61% | 4.047% |
| 15 | 3.296% | 7.567% |
| 20 | 5.751% | 12.661% |
Relationships between endpoints
↥Index endpoint: M13_LIMBPAIN – Pain in limb
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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