muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
369 |
4. Check minimum number of eventsNone |
369 |
5. Include endpointsNone |
369 |
6. Filter based on genotype QC (FinnGen only) |
358 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M79
Name in latin
Hypertrophia corporis adiposi infrapatellaris
Similar endpoints
↥List of similar endpoints to
Hypertrophy of (infrapatellar) fat pad
based on the number of shared cases.
Similar with more cases:
- Other soft tissue disorders, not elsewhere classified
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2650 | 1415 | 1223 |
| Only index persons | 2524 | 1364 | 1160 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 38.04 | 39.91 | 35.86 |
| Only index persons | 37.48 | 39.43 | 35.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 358 | 213 | 145 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.07 |
| Median age at first event (years) | 37.87 | 36.62 | 39.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_FATPADHYPERTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FATPADHYPERTROPHY | 1.243 [0.99, 1.57] | 0.065 |
| Birth year | 0.993 [0.98, 1.0] | 0.123 |
During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 968 females with M13_FATPADHYPERTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FATPADHYPERTROPHY | 1.002 [0.78, 1.29] | 0.987 |
| Birth year | 0.99 [0.98, 1.0] | 0.092 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 711 males with M13_FATPADHYPERTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have M13_FATPADHYPERTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.239% |
| 5 | 0.548% | 1.293% |
| 10 | 1.615% | 3.128% |
| 15 | 3.274% | 6.069% |
| 20 | 5.57% | 10.718% |
Relationships between endpoints
↥Index endpoint: M13_FATPADHYPERTROPHY – Hypertrophy of (infrapatellar) fat pad
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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