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Neuralgia and neuritis, unspecified

EFO MESH Endpoint Browser PheWeb

M13_NEURALGIA

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M79.2
  • Hospital discharge: ICD-9 — 7292
  • Hospital discharge: ICD-8 — 71491
  • Cause of death: ICD-10 — M79.2
  • Cause of death: ICD-9 — 7292
  • Cause of death: ICD-8 — 71491

2 out of 7 registries used, show all original rules.

1811

4. Check minimum number of events

None

1811

5. Include endpoints

None

1811

6. Filter based on genotype QC (FinnGen only)

1750

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M79
Name in latin Neuralgia non specificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13267 7813 5376
Only index persons 12535 7499 5036
Unadjusted period prevalence (%)
Whole population 0.19 0.22 0.15
Only index persons 0.24 0.28 0.19
Median age at first event (years)
Whole population 54.43 54.47 54.50
Only index persons 53.76 53.74 53.78

-FinnGen-

Key figures

All Female Male
Number of individuals 1750 1133 617
Unadjusted period prevalence (%) 0.40 0.44 0.31
Median age at first event (years) 53.83 51.94 57.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_NEURALGIA and mortality.

Females

Parameter HR [95% CI] p-value
M13_NEURALGIA 1.285 [1.13, 1.47] < 0.001
Birth year 0.994 [0.99, 1.0] 0.137

During the follow-up period (1.1.1998 — 31.12.2019), 788 out of 6263 females with M13_NEURALGIA died.

Males

Parameter HR [95% CI] p-value
M13_NEURALGIA 1.324 [1.16, 1.52] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 732 out of 4315 males with M13_NEURALGIA died.

Mortality risk

Mortality risk for people of age

years, who have M13_NEURALGIA.

N-year risk Females Males
1 0.08% 0.252%
5 0.62% 1.395%
10 1.644% 3.671%
15 3.231% 7.091%
20 6.008% 12.535%

Relationships between endpoints

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Index endpoint: M13_NEURALGIA – Neuralgia and neuritis, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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