Residual foreign body in soft tissue

M13_FOREIGNBODY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M79.5
  • Hospital discharge: ICD-9 7296
  • Cause of death: ICD-10 M79.5
  • Cause of death: ICD-9 7296

2 out of 7 registries used, show all original rules.

1842

4. Check minimum number of events

None

1842

5. Include endpoints

None

1842

6. Filter based on genotype QC (FinnGen only)

1772

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M79
Name in latin Corpus alienum residuale in textu molli

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19591 7190 12313
Only index persons 18072 6580 11492
Unadjusted period prevalence (%)
Whole population 0.29 0.21 0.34
Only index persons 0.37 0.24 0.44
Median age at first event (years)
Whole population 37.70 37.66 37.73
Only index persons 39.28 40.24 38.73

-FinnGen-

Key figures

All Female Male
Number of individuals 1772 769 1003
Unadjusted period prevalence (%) 0.42 0.30 0.50
Median age at first event (years) 49.35 46.83 51.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_FOREIGNBODY and mortality.

Females

Parameter HR [95% CI] p-value
M13_FOREIGNBODY 1.084 [0.93, 1.26] 0.289
Birth year 0.996 [0.99, 1.0] 0.316

During the follow-up period (1.1.1998 — 31.12.2019), 373 out of 5944 females with M13_FOREIGNBODY died.

Males

Parameter HR [95% CI] p-value
M13_FOREIGNBODY 1.001 [0.88, 1.14] 0.984
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 706 out of 10385 males with M13_FOREIGNBODY died.

Mortality risk

Mortality risk for people of age

years, who have M13_FOREIGNBODY.

N-year risk Females Males
1 0.099% 0.221%
5 0.567% 1.2%
10 1.552% 2.849%
15 3.177% 5.416%
20 5.588% 9.348%

Relationships between endpoints

Index endpoint: M13_FOREIGNBODY – Residual foreign body in soft tissue

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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