causalgia: Complex regional pain syndrome type 2 (CRPS2), or causalgia is a form of complex regional pain syndrome that develops after damage to a peripheral nerve and is characterized by spontaneous pain, allodynia and hyperalgesia , not necessarily limited to the territory of the injured nerve, as well as at some point, edema, changes in skin blood flow or sudomotor dysfunction in the pain area.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
77552 |
6. Filter based on genotype QC (FinnGen only) |
74560 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Dorsalgia
based on the number of shared cases.
Similar with more cases:
- Dorsopathies
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 664590 | 374723 | 284844 |
| Only index persons | 606243 | 347970 | 258273 |
| Unadjusted period prevalence (%) | |||
| Whole population | 9.50 | 10.73 | 7.96 |
| Only index persons | 11.54 | 12.79 | 9.86 |
| Median age at first event (years) | |||
| Whole population | 49.25 | 50.79 | 47.30 |
| Only index persons | 48.17 | 49.67 | 46.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 74560 | 45974 | 28586 |
| Unadjusted period prevalence (%) | 16.64 | 18.06 | 14.36 |
| Median age at first event (years) | 50.49 | 49.02 | 52.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_DORSALGIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DORSALGIA | 1.296 [1.19, 1.42] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 39788 out of 277239 females with M13_DORSALGIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DORSALGIA | 1.454 [1.32, 1.6] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 30339 out of 202472 males with M13_DORSALGIA died.
Mortality risk
Mortality risk for people of age
years, who have M13_DORSALGIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.252% |
| 5 | 0.593% | 1.451% |
| 10 | 1.498% | 3.659% |
| 15 | 2.995% | 6.699% |
| 20 | 5.084% | 11.529% |
Relationships between endpoints
↥Index endpoint: M13_DORSALGIA – Dorsalgia
GWS hits: 14
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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