No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
24337 |
4. Check minimum number of eventsNone |
24337 |
5. Include endpointsNone |
24337 |
6. Filter based on genotype QC (FinnGen only) |
23458 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF4
Similar endpoints
↥List of similar endpoints to
Sciatica+with lumbago
based on the number of shared cases.
Similar with more cases:
- Lower back pain or/and sciatica
- Dorsalgia
- Dorsopathies
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 175823 | 100824 | 74031 |
| Only index persons | 168115 | 97570 | 70545 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.53 | 2.89 | 2.07 |
| Only index persons | 3.21 | 3.59 | 2.69 |
| Median age at first event (years) | |||
| Whole population | 51.44 | 52.58 | 50.01 |
| Only index persons | 51.14 | 52.24 | 49.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 23458 | 14910 | 8548 |
| Unadjusted period prevalence (%) | 5.29 | 5.86 | 4.29 |
| Median age at first event (years) | 52.91 | 51.90 | 54.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SCIATICA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SCIATICA | 1.1 [1.01, 1.2] | 0.037 |
| Birth year | 0.996 [0.99, 1.0] | 0.339 |
During the follow-up period (1.1.1998 — 31.12.2019), 9165 out of 84331 females with M13_SCIATICA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SCIATICA | 1.137 [1.04, 1.24] | 0.004 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 8100 out of 60565 males with M13_SCIATICA died.
Mortality risk
Mortality risk for people of age
years, who have M13_SCIATICA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.205% |
| 5 | 0.619% | 1.231% |
| 10 | 1.596% | 3.107% |
| 15 | 3.285% | 5.838% |
| 20 | 5.772% | 9.725% |
Relationships between endpoints
↥Index endpoint: M13_SCIATICA – Sciatica+with lumbago
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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