No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
55315 |
6. Filter based on genotype QC (FinnGen only) |
53150 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF4
Similar endpoints
↥List of similar endpoints to
Lower back pain or/and sciatica
based on the number of shared cases.
Similar with more cases:
- Dorsalgia
- Dorsopathies
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 444753 | 251903 | 189907 |
| Only index persons | 419897 | 241099 | 178798 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.37 | 7.22 | 5.31 |
| Only index persons | 8.00 | 8.86 | 6.83 |
| Median age at first event (years) | |||
| Whole population | 50.00 | 51.63 | 47.98 |
| Only index persons | 49.49 | 51.03 | 47.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 53150 | 33145 | 20005 |
| Unadjusted period prevalence (%) | 11.90 | 13.02 | 10.05 |
| Median age at first event (years) | 51.95 | 50.52 | 54.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_LOWBACKPAINORANDSCIATICA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_LOWBACKPAINORANDSCIATICA | 1.231 [1.12, 1.35] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.626 |
During the follow-up period (1.1.1998 — 31.12.2019), 25357 out of 199500 females with M13_LOWBACKPAINORANDSCIATICA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_LOWBACKPAINORANDSCIATICA | 1.367 [1.24, 1.51] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 19820 out of 144981 males with M13_LOWBACKPAINORANDSCIATICA died.
Mortality risk
Mortality risk for people of age
years, who have M13_LOWBACKPAINORANDSCIATICA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.106% | 0.226% |
| 5 | 0.798% | 1.378% |
| 10 | 1.846% | 3.6% |
| 15 | 3.633% | 6.599% |
| 20 | 6.298% | 11.051% |
Relationships between endpoints
↥Index endpoint: M13_LOWBACKPAINORANDSCIATICA – Lower back pain or/and sciatica
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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