No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
39162 |
4. Check minimum number of eventsNone |
39162 |
5. Include endpointsNone |
39162 |
6. Filter based on genotype QC (FinnGen only) |
37567 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M54
Name in latin
Lumbago
Similar endpoints
↥List of similar endpoints to
Low back pain
based on the number of shared cases.
Similar with more cases:
- Lower back pain or/and sciatica
- Dorsalgia
- Dorsopathies
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 321282 | 182872 | 136143 |
| Only index persons | 302858 | 174815 | 128043 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.61 | 5.24 | 3.80 |
| Only index persons | 5.78 | 6.43 | 4.89 |
| Median age at first event (years) | |||
| Whole population | 49.42 | 51.23 | 47.13 |
| Only index persons | 48.85 | 50.57 | 46.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 37567 | 23548 | 14019 |
| Unadjusted period prevalence (%) | 8.42 | 9.25 | 7.04 |
| Median age at first event (years) | 51.70 | 49.96 | 54.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_LOWBACKPAIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_LOWBACKPAIN | 1.406 [1.26, 1.57] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.042 |
During the follow-up period (1.1.1998 — 31.12.2019), 18822 out of 141077 females with M13_LOWBACKPAIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_LOWBACKPAIN | 1.569 [1.4, 1.76] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 13624 out of 100977 males with M13_LOWBACKPAIN died.
Mortality risk
Mortality risk for people of age
years, who have M13_LOWBACKPAIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.105% | 0.323% |
| 5 | 0.665% | 1.505% |
| 10 | 1.661% | 4.107% |
| 15 | 3.409% | 7.71% |
| 20 | 5.951% | 12.911% |
Relationships between endpoints
↥Index endpoint: M13_LOWBACKPAIN – Low back pain
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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