Low back pain

M13_LOWBACKPAIN

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M54.5
  • Hospital discharge: ICD-9 7242
  • Hospital discharge: ICD-8 72870
  • Cause of death: ICD-10 M54.5
  • Cause of death: ICD-9 7242
  • Cause of death: ICD-8 72870

2 out of 7 registries used, show all original rules.

39162

4. Check minimum number of events

None

39162

5. Include endpoints

None

39162

6. Filter based on genotype QC (FinnGen only)

37567

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M54
Name in latin Lumbago

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 321282 182872 136143
Only index persons 302858 174815 128043
Unadjusted period prevalence (%)
Whole population 4.61 5.24 3.80
Only index persons 5.78 6.43 4.89
Median age at first event (years)
Whole population 49.42 51.23 47.13
Only index persons 48.85 50.57 46.51

-FinnGen-

Key figures

All Female Male
Number of individuals 37567 23548 14019
Unadjusted period prevalence (%) 8.42 9.25 7.04
Median age at first event (years) 51.70 49.96 54.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_LOWBACKPAIN and mortality.

Females

Parameter HR [95% CI] p-value
M13_LOWBACKPAIN 1.406 [1.26, 1.57] < 0.001
Birth year 0.992 [0.98, 1.0] 0.042

During the follow-up period (1.1.1998 — 31.12.2019), 18822 out of 141077 females with M13_LOWBACKPAIN died.

Males

Parameter HR [95% CI] p-value
M13_LOWBACKPAIN 1.569 [1.4, 1.76] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 13624 out of 100977 males with M13_LOWBACKPAIN died.

Mortality risk

Mortality risk for people of age

years, who have M13_LOWBACKPAIN.

N-year risk Females Males
1 0.105% 0.323%
5 0.665% 1.505%
10 1.661% 4.107%
15 3.409% 7.71%
20 5.951% 12.911%

Relationships between endpoints

Index endpoint: M13_LOWBACKPAIN – Low back pain

GWS hits: 8

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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