discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
121218 |
4. Check minimum number of eventsNone |
121218 |
5. Include endpoints |
136371 |
6. Filter based on genotype QC (FinnGen only) |
131419 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Dorsopathies
based on the number of shared cases.
Similar with more cases:
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1197038 | 643212 | 544860 |
| Only index persons | 1069700 | 588467 | 481233 |
| Unadjusted period prevalence (%) | |||
| Whole population | 16.90 | 18.42 | 15.22 |
| Only index persons | 20.17 | 21.63 | 18.37 |
| Median age at first event (years) | |||
| Whole population | 49.00 | 50.34 | 47.40 |
| Only index persons | 47.60 | 49.04 | 45.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 131419 | 76454 | 54965 |
| Unadjusted period prevalence (%) | 29.01 | 30.03 | 27.60 |
| Median age at first event (years) | 49.74 | 48.44 | 51.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_DORSOPATHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DORSOPATHY | 1.182 [1.09, 1.28] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.178 |
During the follow-up period (1.1.1998 — 31.12.2019), 60129 out of 450846 females with M13_DORSOPATHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DORSOPATHY | 1.212 [1.12, 1.32] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 53186 out of 359375 males with M13_DORSOPATHY died.
Mortality risk
Mortality risk for people of age
years, who have M13_DORSOPATHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.189% |
| 5 | 0.596% | 1.131% |
| 10 | 1.522% | 2.775% |
| 15 | 2.894% | 5.126% |
| 20 | 5.417% | 8.818% |
Relationships between endpoints
↥Index endpoint: M13_DORSOPATHY – Dorsopathies
GWS hits: 41
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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