scoliosis: A congenital or acquired spinal deformity characterized by lateral curvature of the spine.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
11407 |
4. Check minimum number of eventsNone |
11407 |
5. Include endpoints |
12377 |
6. Filter based on genotype QC (FinnGen only) |
12009 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Deforming dorsopathies
based on the number of shared cases.
Similar with more cases:
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 109109 | 65971 | 42793 |
| Only index persons | 102194 | 62488 | 39706 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.61 | 1.89 | 1.20 |
| Only index persons | 1.99 | 2.30 | 1.52 |
| Median age at first event (years) | |||
| Whole population | 42.90 | 46.02 | 38.00 |
| Only index persons | 42.54 | 45.62 | 37.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12009 | 8083 | 3926 |
| Unadjusted period prevalence (%) | 2.78 | 3.17 | 1.97 |
| Median age at first event (years) | 52.97 | 52.86 | 53.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_DEFORMDORSO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DEFORMDORSO | 1.14 [1.03, 1.26] | 0.013 |
| Birth year | 0.992 [0.98, 1.0] | 0.059 |
During the follow-up period (1.1.1998 — 31.12.2019), 4730 out of 50792 females with M13_DEFORMDORSO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DEFORMDORSO | 1.232 [1.11, 1.36] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 3505 out of 32754 males with M13_DEFORMDORSO died.
Mortality risk
Mortality risk for people of age
years, who have M13_DEFORMDORSO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.192% |
| 5 | 0.514% | 1.413% |
| 10 | 1.375% | 3.577% |
| 15 | 2.801% | 6.546% |
| 20 | 5.078% | 11.361% |
Relationships between endpoints
↥Index endpoint: M13_DEFORMDORSO – Deforming dorsopathies
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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