phimosis: A condition in which there is constriction in the tip of the foreskin resulting in inability to fully retract the foreskin over the glans penis. Causes include balanoposthitis, balanitis xerotica obliterans, and untreated diabetes.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
411 |
4. Check minimum number of eventsNone |
411 |
5. Include endpointsNone |
411 |
6. Filter based on genotype QC (FinnGen only) |
396 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Kyphosis
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4018 | 2016 | 1983 |
| Only index persons | 3629 | 1845 | 1784 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 57.70 | 66.00 | 49.13 |
| Only index persons | 53.54 | 64.43 | 42.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 396 | 239 | 157 |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | 0.08 |
| Median age at first event (years) | 63.40 | 63.76 | 62.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_KYPHOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_KYPHOSIS | 1.762 [1.47, 2.11] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.67 |
During the follow-up period (1.1.1998 — 31.12.2019), 324 out of 1582 females with M13_KYPHOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_KYPHOSIS | 1.699 [1.37, 2.1] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 334 out of 1602 males with M13_KYPHOSIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_KYPHOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.219% | 0.331% |
| 5 | 1.156% | 2.032% |
| 10 | 2.702% | 4.863% |
| 15 | 5.535% | 8.989% |
| 20 | 9.47% | 14.798% |
Relationships between endpoints
↥Index endpoint: M13_KYPHOSIS – Kyphosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data