spondylolisthesis: A condition in which there is forward displacement of a vertebral bone over the on below it.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7270 |
4. Check minimum number of eventsNone |
7270 |
5. Include endpointsNone |
7270 |
6. Filter based on genotype QC (FinnGen only) |
7098 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Spondylolisthesis/Spondylolysis
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 48651 | 28486 | 20045 |
| Only index persons | 47184 | 27814 | 19370 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.71 | 0.82 | 0.56 |
| Only index persons | 0.91 | 1.02 | 0.74 |
| Median age at first event (years) | |||
| Whole population | 54.63 | 57.47 | 50.61 |
| Only index persons | 54.46 | 57.28 | 50.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7098 | 4588 | 2510 |
| Unadjusted period prevalence (%) | 1.61 | 1.80 | 1.26 |
| Median age at first event (years) | 56.74 | 57.10 | 56.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPONDYLOLISTHESIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOLISTHESIS | 0.957 [0.86, 1.07] | 0.426 |
| Birth year | 0.995 [0.99, 1.0] | 0.204 |
During the follow-up period (1.1.1998 — 31.12.2019), 2409 out of 24174 females with M13_SPONDYLOLISTHESIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOLISTHESIS | 1.056 [0.95, 1.18] | 0.323 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 1963 out of 16826 males with M13_SPONDYLOLISTHESIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPONDYLOLISTHESIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.238% |
| 5 | 0.591% | 1.269% |
| 10 | 1.443% | 3.212% |
| 15 | 2.637% | 6.173% |
| 20 | 4.882% | 10.728% |
Relationships between endpoints
↥Index endpoint: M13_SPONDYLOLISTHESIS – Spondylolisthesis/Spondylolysis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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