scoliosis: A congenital or acquired spinal deformity characterized by lateral curvature of the spine.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3376 |
4. Check minimum number of eventsNone |
3376 |
5. Include endpointsNone |
3376 |
6. Filter based on genotype QC (FinnGen only) |
3244 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M40-M43
Name in latin
Scoliosis
Similar endpoints
↥List of similar endpoints to
Scoliosis
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 38872 | 27090 | 11687 |
| Only index persons | 36962 | 25950 | 11012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.64 | 0.78 | 0.33 |
| Only index persons | 0.80 | 0.95 | 0.42 |
| Median age at first event (years) | |||
| Whole population | 15.30 | 15.00 | 15.65 |
| Only index persons | 15.17 | 14.98 | 15.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3244 | 2548 | 696 |
| Unadjusted period prevalence (%) | 0.86 | 1.00 | 0.35 |
| Median age at first event (years) | 44.17 | 43.48 | 46.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SCOLIOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SCOLIOSIS | 1.588 [1.36, 1.85] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 1446 out of 21884 females with M13_SCOLIOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SCOLIOSIS | 1.838 [1.55, 2.18] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 708 out of 9574 males with M13_SCOLIOSIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_SCOLIOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.138% | 0.331% |
| 5 | 0.947% | 2.23% |
| 10 | 2.334% | 5.594% |
| 15 | 4.385% | 10.075% |
| 20 | 7.4% | 17.252% |
Relationships between endpoints
↥Index endpoint: M13_SCOLIOSIS – Scoliosis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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