No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
211 |
4. Check minimum number of eventsNone |
211 |
5. Include endpointsNone |
211 |
6. Filter based on genotype QC (FinnGen only) |
206 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Atlantoaxial subluxation
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1586 | 993 | 576 |
| Only index persons | 1308 | 813 | 495 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 61.59 | 53.21 |
| Only index persons | 56.40 | 59.48 | 51.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 206 | 135 | 71 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 53.56 | 52.92 | 54.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_ATLOAXSUBLUX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ATLOAXSUBLUX | 2.573 [2.2, 3.01] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 298 out of 797 females with M13_ATLOAXSUBLUX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ATLOAXSUBLUX | 1.478 [1.18, 1.85] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 500 males with M13_ATLOAXSUBLUX died.
Mortality risk
Mortality risk for people of age
years, who have M13_ATLOAXSUBLUX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.239% |
| 5 | 1.353% | 1.353% |
| 10 | 3.347% | 3.58% |
| 15 | 6.752% | 6.956% |
| 20 | 11.712% | 11.871% |
Relationships between endpoints
↥Index endpoint: M13_ATLOAXSUBLUX – Atlantoaxial subluxation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data