No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
396 |
4. Check minimum number of eventsNone |
396 |
5. Include endpointsNone |
396 |
6. Filter based on genotype QC (FinnGen only) |
384 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M40-M43
Name in latin
Osteochondrosis spinalis
Similar endpoints
↥List of similar endpoints to
Spinal osteochondrosis
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4271 | 1626 | 2630 |
| Only index persons | 4030 | 1537 | 2493 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.07 |
| Only index persons | 0.08 | 0.06 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 35.52 | 48.47 | 27.38 |
| Only index persons | 33.50 | 46.39 | 25.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 384 | 181 | 203 |
| Unadjusted period prevalence (%) | 0.09 | 0.07 | 0.10 |
| Median age at first event (years) | 41.48 | 42.99 | 40.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPINALOSTEOCHON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPINALOSTEOCHON | 1.195 [1.02, 1.41] | 0.031 |
| Birth year | 0.994 [0.99, 1.0] | 0.182 |
During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 1341 females with M13_SPINALOSTEOCHON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPINALOSTEOCHON | 1.222 [1.01, 1.48] | 0.041 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 212 out of 1938 males with M13_SPINALOSTEOCHON died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPINALOSTEOCHON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | 0.219% |
| 5 | 0.877% | 1.405% |
| 10 | 1.929% | 3.729% |
| 15 | 3.596% | 6.762% |
| 20 | 6.181% | 11.273% |
Relationships between endpoints
↥Index endpoint: M13_SPINALOSTEOCHON – Spinal osteochondrosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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