No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
9030 |
4. Check minimum number of eventsNone |
9030 |
5. Include endpoints |
9454 |
6. Filter based on genotype QC (FinnGen only) |
9136 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M70-M79
Name in latin
Enthesopathiae membri inferioris pede excepto
Similar endpoints
↥List of similar endpoints to
Enthesopathies of lower limb, excluding foot
based on the number of shared cases.
Similar with more cases:
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 63535 | 34055 | 29249 |
| Only index persons | 61590 | 33269 | 28321 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.90 | 0.98 | 0.82 |
| Only index persons | 1.16 | 1.22 | 1.08 |
| Median age at first event (years) | |||
| Whole population | 47.77 | 50.98 | 44.05 |
| Only index persons | 47.64 | 50.88 | 43.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9136 | 5690 | 3446 |
| Unadjusted period prevalence (%) | 2.04 | 2.23 | 1.73 |
| Median age at first event (years) | 52.38 | 52.51 | 52.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ENTESOPATHYLOW and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ENTESOPATHYLOW | 0.924 [0.83, 1.03] | 0.142 |
| Birth year | 1.0 [0.99, 1.01] | 0.986 |
During the follow-up period (1.1.1998 — 31.12.2019), 2072 out of 26588 females with M13_ENTESOPATHYLOW died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ENTESOPATHYLOW | 0.863 [0.78, 0.96] | 0.005 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 1895 out of 21564 males with M13_ENTESOPATHYLOW died.
Mortality risk
Mortality risk for people of age
years, who have M13_ENTESOPATHYLOW.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.108% | 0.118% |
| 5 | 0.637% | 0.87% |
| 10 | 1.641% | 2.381% |
| 15 | 3.086% | 4.737% |
| 20 | 5.409% | 8.139% |
Relationships between endpoints
↥Index endpoint: M13_ENTESOPATHYLOW – Enthesopathies of lower limb, excluding foot
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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