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Other intervertebral disc disorders

DOID EFO Endpoint Browser PheWeb

M13_INTERVERTEB

lumbar disc degeneration: Any disease of a degenerative nature that affects the intervertebral disc.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M51
  • Hospital discharge: ICD-9 — 722
  • Hospital discharge: ICD-8 — 725
  • Hospital discharge: excluded ICD-9 — 7220|7224|7227|7228A
  • Hospital discharge: excluded ICD-8 — 7250
  • Cause of death: ICD-10 — M51
  • Cause of death: ICD-9 — 722
  • Cause of death: ICD-8 — 725
  • Cause of death: excluded ICD-9 — 7220|7224|7227|7228A
  • Cause of death: excluded ICD-8 — 7250

2 out of 7 registries used, show all original rules.

47782

4. Check minimum number of events

None

47782

5. Include endpoints

None

47782

6. Filter based on genotype QC (FinnGen only)

46205

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M50-M54
Name in latin Aliae morbositates discorum intervertebralium

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 361216 182083 177156
Only index persons 337293 173994 163299
Unadjusted period prevalence (%)
Whole population 5.07 5.22 4.95
Only index persons 6.32 6.40 6.23
Median age at first event (years)
Whole population 48.22 49.60 46.80
Only index persons 47.83 49.27 46.30

-FinnGen-

Key figures

All Female Male
Number of individuals 46205 26114 20091
Unadjusted period prevalence (%) 10.18 10.26 10.09
Median age at first event (years) 49.36 48.83 50.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_INTERVERTEB and mortality.

Females

Parameter HR [95% CI] p-value
M13_INTERVERTEB 0.96 [0.88, 1.04] 0.338
Birth year 0.996 [0.99, 1.0] 0.357

During the follow-up period (1.1.1998 — 31.12.2019), 12770 out of 139800 females with M13_INTERVERTEB died.

Males

Parameter HR [95% CI] p-value
M13_INTERVERTEB 1.019 [0.94, 1.1] 0.655
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 15026 out of 129744 males with M13_INTERVERTEB died.

Mortality risk

Mortality risk for people of age

years, who have M13_INTERVERTEB.

N-year risk Females Males
1 0.11% 0.167%
5 0.548% 1.074%
10 1.392% 2.659%
15 2.709% 4.964%
20 4.762% 8.401%

Relationships between endpoints

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Index endpoint: M13_INTERVERTEB – Other intervertebral disc disorders

GWS hits: 40

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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