ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
45836 |
4. Check minimum number of eventsNone |
45836 |
5. Include endpoints |
48247 |
6. Filter based on genotype QC (FinnGen only) |
46755 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Spondylopathies
based on the number of shared cases.
Similar with more cases:
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 367998 | 193655 | 171564 |
| Only index persons | 317161 | 172034 | 145127 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.18 | 5.55 | 4.79 |
| Only index persons | 5.97 | 6.32 | 5.54 |
| Median age at first event (years) | |||
| Whole population | 59.70 | 61.03 | 58.17 |
| Only index persons | 58.75 | 60.04 | 57.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 46755 | 25149 | 21606 |
| Unadjusted period prevalence (%) | 10.33 | 9.88 | 10.85 |
| Median age at first event (years) | 58.58 | 57.91 | 59.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPONDYLOPATHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOPATHY | 1.088 [1.01, 1.18] | 0.033 |
| Birth year | 0.995 [0.99, 1.0] | 0.211 |
During the follow-up period (1.1.1998 — 31.12.2019), 26563 out of 141151 females with M13_SPONDYLOPATHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOPATHY | 1.173 [1.08, 1.28] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 26315 out of 119872 males with M13_SPONDYLOPATHY died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPONDYLOPATHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.208% |
| 5 | 0.528% | 1.417% |
| 10 | 1.408% | 3.544% |
| 15 | 2.861% | 6.609% |
| 20 | 5.11% | 11.056% |
Relationships between endpoints
↥Index endpoint: M13_SPONDYLOPATHY – Spondylopathies
GWS hits: 30
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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