discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
508 |
4. Check minimum number of eventsNone |
508 |
5. Include endpointsNone |
508 |
6. Filter based on genotype QC (FinnGen only) |
495 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Discitis, unspecified based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases related-to ILD
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 3832 | 1518 | 2294 |
Only index persons | 3640 | 1453 | 2187 |
Unadjusted period prevalence (%) | |||
Whole population | 0.06 | 0.04 | 0.06 |
Only index persons | 0.07 | 0.05 | 0.08 |
Median age at first event (years) | |||
Whole population | 64.99 | 67.41 | 63.41 |
Only index persons | 64.70 | 66.94 | 63.21 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 495 | 184 | 311 |
Unadjusted period prevalence (%) | 0.12 | 0.07 | 0.16 |
Median age at first event (years) | 65.97 | 64.61 | 66.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_DISCITIS and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
M13_DISCITIS | 2.337 [1.84, 2.97] | < 0.001 |
Birth year | 0.997 [0.99, 1.01] | 0.524 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1285 females with M13_DISCITIS died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
M13_DISCITIS | 2.407 [1.94, 2.98] | < 0.001 |
Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 569 out of 1892 males with M13_DISCITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_DISCITIS.N-year risk | Females | Males |
---|---|---|
1 | 0.203% | 0.437% |
5 | 1.306% | 2.524% |
10 | 3.654% | 6.535% |
15 | 7.338% | 12.408% |
20 | 12.465% | 20.51% |
Relationships between endpoints
↥Index endpoint: M13_DISCITIS – Discitis, unspecified
GWS hits: 1