Discitis, unspecified

M13_DISCITIS

discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M46.4
  • Cause of death: ICD-10 M46.4

2 out of 7 registries used, show all original rules.

508

4. Check minimum number of events

None

508

5. Include endpoints

None

508

6. Filter based on genotype QC (FinnGen only)

495

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M46
Name in latin Discitis non specificata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3832 1518 2294
Only index persons 3640 1453 2187
Unadjusted period prevalence (%)
Whole population 0.06 0.04 0.06
Only index persons 0.07 0.05 0.08
Median age at first event (years)
Whole population 64.99 67.41 63.41
Only index persons 64.70 66.94 63.21

-FinnGen-

Key figures

All Female Male
Number of individuals 495 184 311
Unadjusted period prevalence (%) 0.12 0.07 0.16
Median age at first event (years) 65.97 64.61 66.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_DISCITIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_DISCITIS 2.337 [1.84, 2.97] < 0.001
Birth year 0.997 [0.99, 1.01] 0.524

During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1285 females with M13_DISCITIS died.

Males

Parameter HR [95% CI] p-value
M13_DISCITIS 2.407 [1.94, 2.98] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 569 out of 1892 males with M13_DISCITIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_DISCITIS.

N-year risk Females Males
1 0.203% 0.437%
5 1.306% 2.524%
10 3.654% 6.535%
15 7.338% 12.408%
20 12.465% 20.51%

Relationships between endpoints

Index endpoint: M13_DISCITIS – Discitis, unspecified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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