No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
5924 |
6. Filter based on genotype QC (FinnGen only) |
5703 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Spondylopathies (FG)
based on the number of shared cases.
Similar with more cases:
- Spondyloarthritis
- Autoimmune diseases related-to ILD
- Spondylopathies
- Finngen Rheumatological endpoints
- Dorsopathies
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 39812 | 19066 | 20507 |
| Only index persons | 36761 | 18231 | 18530 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.56 | 0.55 | 0.57 |
| Only index persons | 0.69 | 0.67 | 0.71 |
| Median age at first event (years) | |||
| Whole population | 40.19 | 40.73 | 39.58 |
| Only index persons | 39.24 | 40.12 | 38.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5703 | 3169 | 2534 |
| Unadjusted period prevalence (%) | 1.26 | 1.24 | 1.27 |
| Median age at first event (years) | 40.82 | 40.14 | 41.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint SPONDYLOPATHY_FG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SPONDYLOPATHY_FG | 1.297 [1.16, 1.46] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.145 |
During the follow-up period (1.1.1998 — 31.12.2019), 923 out of 14784 females with SPONDYLOPATHY_FG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SPONDYLOPATHY_FG | 1.276 [1.15, 1.41] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1385 out of 13601 males with SPONDYLOPATHY_FG died.
Mortality risk
Mortality risk for people of age
years, who have SPONDYLOPATHY_FG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.224% |
| 5 | 0.729% | 1.405% |
| 10 | 2.033% | 3.6% |
| 15 | 3.661% | 6.856% |
| 20 | 6.263% | 11.253% |
Relationships between endpoints
↥Index endpoint: SPONDYLOPATHY_FG – Spondylopathies (FG)
GWS hits: 17
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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