No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7978 |
4. Check minimum number of eventsNone |
7978 |
5. Include endpointsNone |
7978 |
6. Filter based on genotype QC (FinnGen only) |
7700 |
Control definitions (FinnGen only)
Control exclude
ILD_SYST_AUTO_DISEASES
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Spondyloarthritis
based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases related-to ILD
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 77792 | 37939 | 38710 |
| Only index persons | 54653 | 28037 | 26616 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.09 | 1.09 | 1.08 |
| Only index persons | 1.02 | 1.03 | 1.02 |
| Median age at first event (years) | |||
| Whole population | 50.27 | 50.96 | 49.42 |
| Only index persons | 44.82 | 46.02 | 43.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7700 | 3880 | 3820 |
| Unadjusted period prevalence (%) | 1.72 | 1.52 | 1.92 |
| Median age at first event (years) | 44.66 | 42.41 | 46.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint SPONDYLOARTHRITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SPONDYLOARTHRITIS | 1.517 [1.35, 1.7] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.067 |
During the follow-up period (1.1.1998 — 31.12.2019), 1511 out of 17008 females with SPONDYLOARTHRITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SPONDYLOARTHRITIS | 1.508 [1.36, 1.67] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2391 out of 16907 males with SPONDYLOARTHRITIS died.
Mortality risk
Mortality risk for people of age
years, who have SPONDYLOARTHRITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.129% | 0.277% |
| 5 | 0.784% | 1.693% |
| 10 | 1.946% | 4.195% |
| 15 | 3.745% | 7.792% |
| 20 | 6.387% | 13.433% |
Relationships between endpoints
↥Index endpoint: SPONDYLOARTHRITIS – Spondyloarthritis
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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