ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
3390 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
1586 |
4. Check minimum number of eventsNone |
1586 |
5. Include endpointsNone |
1586 |
6. Filter based on genotype QC (FinnGen only) |
1521 |
Control definitions (FinnGen only)
Control conditions
not M13_ANKYLOSPON_ICD10
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Ankylosing spondylitis, strict definition
based on the number of shared cases.
Similar with more cases:
- Ankylosing spondylitis, ICD10
- Ankylosing spondylitis
- Spondylopathies (FG)
- Spondyloarthritis
- Autoimmune diseases related-to ILD
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8672 | 3328 | 5319 |
| Only index persons | 8532 | 3302 | 5230 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.10 | 0.15 |
| Only index persons | 0.17 | 0.12 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 37.75 | 38.28 | 37.43 |
| Only index persons | 37.70 | 38.29 | 37.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1521 | 706 | 815 |
| Unadjusted period prevalence (%) | 0.35 | 0.28 | 0.41 |
| Median age at first event (years) | 39.28 | 38.35 | 40.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ANKYLOSPON_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ANKYLOSPON_STRICT | 0.709 [0.53, 0.95] | 0.019 |
| Birth year | 0.993 [0.98, 1.0] | 0.138 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 2980 females with M13_ANKYLOSPON_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ANKYLOSPON_STRICT | 0.829 [0.71, 0.96] | 0.015 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 4769 males with M13_ANKYLOSPON_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have M13_ANKYLOSPON_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.071% | 0.139% |
| 5 | 0.43% | 1.001% |
| 10 | 1.008% | 2.594% |
| 15 | 1.862% | 4.725% |
| 20 | 3.295% | 8.268% |
Relationships between endpoints
↥Index endpoint: M13_ANKYLOSPON_STRICT – Ankylosing spondylitis, strict definition
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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