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Sacroiliitis, not elsewhere classified

EFO MESH Endpoint Browser PheWeb

M13_SACROILIITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M46.1
  • Hospital discharge: ICD-9 — 7202
  • Hospital discharge: ICD-8 — 72699
  • Cause of death: ICD-10 — M46.1
  • Cause of death: ICD-9 — 7202
  • Cause of death: ICD-8 — 72699

2 out of 7 registries used, show all original rules.

1851

4. Check minimum number of events

None

1851

5. Include endpoints

None

1851

6. Filter based on genotype QC (FinnGen only)

1765

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M46
Name in latin Sacroiliitis non alibi classificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11257 6845 4374
Only index persons 10866 6650 4216
Unadjusted period prevalence (%)
Whole population 0.17 0.20 0.12
Only index persons 0.21 0.24 0.16
Median age at first event (years)
Whole population 36.39 38.05 33.77
Only index persons 36.06 37.77 33.36

-FinnGen-

Key figures

All Female Male
Number of individuals 1765 1221 544
Unadjusted period prevalence (%) 0.42 0.48 0.27
Median age at first event (years) 38.01 38.02 37.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_SACROILIITIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_SACROILIITIS 1.026 [0.86, 1.22] 0.771
Birth year 1.0 [0.99, 1.01] 0.952

During the follow-up period (1.1.1998 — 31.12.2019), 189 out of 5262 females with M13_SACROILIITIS died.

Males

Parameter HR [95% CI] p-value
M13_SACROILIITIS 1.109 [0.93, 1.32] 0.239
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 3252 males with M13_SACROILIITIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_SACROILIITIS.

N-year risk Females Males
1 0.093% 0.222%
5 0.627% 1.331%
10 1.608% 3.293%
15 3.278% 6.163%
20 5.972% 10.583%

Relationships between endpoints

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Index endpoint: M13_SACROILIITIS – Sacroiliitis, not elsewhere classified

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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