No definition available.
Other specified/unspecified inflammatory spondylopathies
DOID EFO Endpoint Browser PheWeb
M13_SPONDYLINFLAMNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1833 |
4. Check minimum number of eventsNone |
1833 |
5. Include endpointsNone |
1833 |
6. Filter based on genotype QC (FinnGen only) |
1772 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified inflammatory spondylopathies
based on the number of shared cases.
Similar with more cases:
- Spondylopathies (FG)
- Autoimmune diseases related-to ILD
- Spondylopathies
- Finngen Rheumatological endpoints
- Dorsopathies
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11100 | 6611 | 4434 |
| Only index persons | 10586 | 6400 | 4186 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.19 | 0.12 |
| Only index persons | 0.21 | 0.24 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 43.02 | 42.94 | 43.03 |
| Only index persons | 42.21 | 42.34 | 42.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1772 | 1195 | 577 |
| Unadjusted period prevalence (%) | 0.41 | 0.47 | 0.29 |
| Median age at first event (years) | 44.04 | 43.36 | 45.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPONDYLINFLAMNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLINFLAMNAS | 1.224 [1.04, 1.44] | 0.014 |
| Birth year | 1.0 [0.99, 1.01] | 0.97 |
During the follow-up period (1.1.1998 — 31.12.2019), 297 out of 5780 females with M13_SPONDYLINFLAMNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLINFLAMNAS | 1.518 [1.31, 1.76] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 390 out of 3635 males with M13_SPONDYLINFLAMNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPONDYLINFLAMNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.256% |
| 5 | 0.817% | 1.557% |
| 10 | 2.133% | 4.122% |
| 15 | 4.094% | 7.724% |
| 20 | 7.452% | 13.285% |
Relationships between endpoints
↥Index endpoint: M13_SPONDYLINFLAMNAS – Other specified/unspecified inflammatory spondylopathies
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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