Other infective spondylopathies

M13_SPONDYLOINFECTION

spondyloarthropathy: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M46.5
  • Cause of death: ICD-10 M46.5

2 out of 7 registries used, show all original rules.

69

4. Check minimum number of events

None

69

5. Include endpoints

None

69

6. Filter based on genotype QC (FinnGen only)

68

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M46
Name in latin Aliae spondylopathiae infectiosae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 542 218 318
Only index persons 472 194 278
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 62.03 62.76 61.63
Only index persons 61.15 61.14 61.16

-FinnGen-

Key figures

All Female Male
Number of individuals 68 30 38
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 61.53 60.93 62.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint M13_SPONDYLOINFECTION and mortality.

Females

Parameter HR [95% CI] p-value
M13_SPONDYLOINFECTION 1.757 [1.21, 2.55] 0.003
Birth year 0.998 [0.99, 1.01] 0.609

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 189 females with M13_SPONDYLOINFECTION died.

Males

Parameter HR [95% CI] p-value
M13_SPONDYLOINFECTION 1.879 [1.35, 2.62] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 102 out of 266 males with M13_SPONDYLOINFECTION died.

Mortality risk

Mortality risk for people of age

years, who have M13_SPONDYLOINFECTION.

N-year risk Females Males
1 0.202% 0.326%
5 1.082% 2.174%
10 2.763% 5.34%
15 5.439% 9.837%
20 9.668% 17.039%

Relationships between endpoints

Index endpoint: M13_SPONDYLOINFECTION – Other infective spondylopathies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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