No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1389 |
4. Check minimum number of eventsNone |
1389 |
5. Include endpointsNone |
1389 |
6. Filter based on genotype QC (FinnGen only) |
1350 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
M46
Name in latin
Enthesopathia spinalis
Similar endpoints
↥List of similar endpoints to
Spinal enthesopathy
based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases related-to ILD
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 33053 | 17098 | 15067 |
| Only index persons | 13197 | 8115 | 5082 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.49 | 0.42 |
| Only index persons | 0.26 | 0.30 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 55.76 | 56.06 | 55.36 |
| Only index persons | 50.71 | 51.48 | 49.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1350 | 522 | 828 |
| Unadjusted period prevalence (%) | 0.33 | 0.21 | 0.42 |
| Median age at first event (years) | 49.68 | 48.30 | 50.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPINENTHES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPINENTHES | 1.453 [1.13, 1.87] | 0.004 |
| Birth year | 0.996 [0.99, 1.01] | 0.406 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 699 females with M13_SPINENTHES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPINENTHES | 1.31 [1.04, 1.65] | 0.022 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 629 males with M13_SPINENTHES died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPINENTHES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.208% |
| 5 | 0.821% | 1.478% |
| 10 | 2.233% | 3.758% |
| 15 | 4.166% | 7.268% |
| 20 | 7.308% | 12.053% |
Relationships between endpoints
↥Index endpoint: M13_SPINENTHES – Spinal enthesopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data