No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
25149 |
4. Check minimum number of eventsNone |
25149 |
5. Include endpointsNone |
25149 |
6. Filter based on genotype QC (FinnGen only) |
24345 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M45-M49
Name in latin
Spondylosis
Similar endpoints
↥List of similar endpoints to
Spondylosis
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 176743 | 94465 | 81168 |
| Only index persons | 157735 | 86592 | 71143 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.49 | 2.71 | 2.27 |
| Only index persons | 2.97 | 3.18 | 2.72 |
| Median age at first event (years) | |||
| Whole population | 59.47 | 60.41 | 58.26 |
| Only index persons | 58.23 | 59.23 | 57.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 24345 | 13630 | 10715 |
| Unadjusted period prevalence (%) | 5.37 | 5.35 | 5.38 |
| Median age at first event (years) | 58.25 | 57.61 | 59.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPONDYLOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOSIS | 1.053 [0.97, 1.14] | 0.215 |
| Birth year | 0.997 [0.99, 1.0] | 0.433 |
During the follow-up period (1.1.1998 — 31.12.2019), 11491 out of 73198 females with M13_SPONDYLOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOSIS | 1.072 [0.99, 1.17] | 0.101 |
| Birth year | 0.991 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 11365 out of 61023 males with M13_SPONDYLOSIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPONDYLOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.197% |
| 5 | 0.614% | 1.34% |
| 10 | 1.545% | 3.54% |
| 15 | 2.974% | 6.731% |
| 20 | 5.326% | 11.351% |
Relationships between endpoints
↥Index endpoint: M13_SPONDYLOSIS – Spondylosis
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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