spinal stenosis: Narrowing of the spinal canal.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
23775 |
4. Check minimum number of eventsNone |
23775 |
5. Include endpointsNone |
23775 |
6. Filter based on genotype QC (FinnGen only) |
23153 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M48
Name in latin
Stenosis spinalis
Similar endpoints
↥List of similar endpoints to
Spinal stenosis
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 163807 | 88973 | 74037 |
| Only index persons | 150765 | 83430 | 67335 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.32 | 2.55 | 2.07 |
| Only index persons | 2.85 | 3.07 | 2.57 |
| Median age at first event (years) | |||
| Whole population | 66.83 | 68.57 | 64.71 |
| Only index persons | 66.35 | 68.15 | 64.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 23153 | 12254 | 10899 |
| Unadjusted period prevalence (%) | 5.12 | 4.81 | 5.47 |
| Median age at first event (years) | 65.10 | 64.70 | 65.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPINSTENOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPINSTENOSIS | 1.009 [0.93, 1.09] | 0.823 |
| Birth year | 0.999 [0.99, 1.01] | 0.858 |
During the follow-up period (1.1.1998 — 31.12.2019), 17303 out of 73694 females with M13_SPINSTENOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPINSTENOSIS | 1.151 [1.06, 1.25] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 16425 out of 59811 males with M13_SPINSTENOSIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPINSTENOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.208% |
| 5 | 0.654% | 1.28% |
| 10 | 1.645% | 3.229% |
| 15 | 3.206% | 6.397% |
| 20 | 5.688% | 10.771% |
Relationships between endpoints
↥Index endpoint: M13_SPINSTENOSIS – Spinal stenosis
GWS hits: 40
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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