No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
847 |
4. Check minimum number of eventsNone |
847 |
5. Include endpointsNone |
847 |
6. Filter based on genotype QC (FinnGen only) |
816 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified spondylopathies
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6865 | 3859 | 2962 |
| Only index persons | 6209 | 3561 | 2648 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.11 | 0.08 |
| Only index persons | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 68.14 | 70.49 | 65.01 |
| Only index persons | 67.04 | 69.66 | 63.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 816 | 446 | 370 |
| Unadjusted period prevalence (%) | 0.18 | 0.18 | 0.19 |
| Median age at first event (years) | 64.49 | 62.90 | 66.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPONDYLOPATHYNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOPATHYNAS | 1.386 [1.25, 1.54] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.376 |
During the follow-up period (1.1.1998 — 31.12.2019), 1275 out of 3536 females with M13_SPONDYLOPATHYNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOPATHYNAS | 1.517 [1.34, 1.72] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.075 |
During the follow-up period (1.1.1998 — 31.12.2019), 1020 out of 2652 males with M13_SPONDYLOPATHYNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPONDYLOPATHYNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.262% |
| 5 | 0.832% | 1.793% |
| 10 | 2.113% | 4.895% |
| 15 | 4.274% | 9.13% |
| 20 | 7.471% | 16.101% |
Relationships between endpoints
↥Index endpoint: M13_SPONDYLOPATHYNAS – Other specified/unspecified spondylopathies
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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