spinal stenosis: Narrowing of the spinal canal.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
243 |
4. Check minimum number of eventsNone |
243 |
5. Include endpointsNone |
243 |
6. Filter based on genotype QC (FinnGen only) |
237 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M48
Name in latin
Vertebra collapsa non alibi classificata
Similar endpoints
↥List of similar endpoints to
Collapsed vertebra, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2977 | 1951 | 1011 |
| Only index persons | 2606 | 1732 | 874 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 76.32 | 78.64 | 71.80 |
| Only index persons | 76.04 | 78.45 | 71.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 237 | 154 | 83 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | 73.29 | 74.06 | 71.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_VERTEBCOLLAPSE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VERTEBCOLLAPSE | 1.885 [1.61, 2.21] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.355 |
During the follow-up period (1.1.1998 — 31.12.2019), 934 out of 1714 females with M13_VERTEBCOLLAPSE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VERTEBCOLLAPSE | 2.57 [1.93, 3.42] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 886 males with M13_VERTEBCOLLAPSE died.
Mortality risk
Mortality risk for people of age
years, who have M13_VERTEBCOLLAPSE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.216% | 0.475% |
| 5 | 1.281% | 3.061% |
| 10 | 3.045% | 7.447% |
| 15 | 5.762% | 13.539% |
| 20 | 9.692% | 22.336% |
Relationships between endpoints
↥Index endpoint: M13_VERTEBCOLLAPSE – Collapsed vertebra, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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