No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
383 |
4. Check minimum number of eventsNone |
383 |
5. Include endpointsNone |
383 |
6. Filter based on genotype QC (FinnGen only) |
375 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M46
Name in latin
Infectio disci intervertebralis (pyogenes)
Similar endpoints
↥List of similar endpoints to
Infection of intervertebral disc (pyogenic)
based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases related-to ILD
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2789 | 1003 | 1779 |
| Only index persons | 2627 | 945 | 1682 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.03 | 0.05 |
| Only index persons | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 64.58 | 68.10 | 62.60 |
| Only index persons | 64.18 | 67.66 | 62.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 375 | 110 | 265 |
| Unadjusted period prevalence (%) | 0.11 | 0.04 | 0.13 |
| Median age at first event (years) | 66.42 | 68.81 | 65.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_DISCINFECTION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DISCINFECTION | 2.197 [1.72, 2.81] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 208 out of 774 females with M13_DISCINFECTION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DISCINFECTION | 2.163 [1.73, 2.7] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 430 out of 1413 males with M13_DISCINFECTION died.
Mortality risk
Mortality risk for people of age
years, who have M13_DISCINFECTION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.152% | 0.427% |
| 5 | 1.139% | 2.451% |
| 10 | 2.617% | 5.546% |
| 15 | 5.3% | 10.663% |
| 20 | 9.26% | 18.144% |
Relationships between endpoints
↥Index endpoint: M13_DISCINFECTION – Infection of intervertebral disc (pyogenic)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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